162 / 165
Incompatible materials
See section 7
Hazardous decomposition
products
See section 5
SECTION 11 TOXICOLOGICAL INFORMATION
Information on toxicological effects
Inhaled
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC Directives using animal models).
Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
Ingestion
The material has
NOT
been classified by EC Directives or other classification systems as "harmful by ingestion". This is because of the lack of
corroborating animal or human evidence.
Skin Contact
There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the
use of the material and ensure that any external damage is suitably protected.
Eye
There is some evidence to suggest that this material can cause eye irritation and damage in some persons.
Chronic
Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure.
There is limited evidence that, skin contact with this product is more likely to cause a sensitisation reaction in some persons compared to the general
population.
NV Chemicals Sugar Soap
Liquid
TOXICITY
IRRITATION
Not Available
Not Available
trisodium phosphate
TOXICITY
IRRITATION
dermal (rat) LD50: >2000 mg/kg
[1]
Eye (rabbit):(FSHA) Corrosive*
Oral (rat) LD50: >500 mg/kg
[1]
Skin (rabbit):(FSHA) 3.3 on a
coconut diethanolamide
TOXICITY
IRRITATION
Inhalation (rat) LC50: 87.899592 mg/l/h*
[2]
Not Available
Oral (rat) LD50: 2700 mg/kg
[2]
cocamidopropylbetaine
TOXICITY
IRRITATION
Oral (rat) LD50: 2700 mg/kg
[2]
Eye: primary irritant *
Skin: primary irritant *
water
TOXICITY
IRRITATION
Not Available
Not Available
Legend:
1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2.* Value obtained from manufacturer's SDS. Unless otherwise specified
data extracted from RTECS - Register of Toxic Effect of chemical Substances
TRISODIUM PHOSPHATE
Asthma-like symptoms may continue for months or even years after exposure to the material ends. This may be due to a non-allergic condition known as
reactive airways dysfunction syndrome (RADS) which can occur after exposure to high levels of highly irritating compound. Main criteria for diagnosing
RADS include the absence of previous airways disease in a non-atopic individual, with sudden onset of persistent asthma-like symptoms within minutes to
hours of a documented exposure to the irritant. Other criteria for diagnosis of RADS include a reversible airflow pattern on lung function tests, moderate to
severe bronchial hyperreactivity on methacholine challenge testing, and the lack of minimal lymphocytic inflammation, without eosinophilia.
COCAMIDOPROPYLBETAINE
The following information refers to contact allergens as a group and may not be specific to this product.
Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of contact eczema
involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated
immune reactions.
Possible cross-reactions to several fatty acid amidopropyl dimethylamines were observed in patients that were reported to have allergic contact dermatitis
to a baby lotion that contained 0.3% oleamidopropyl dimethylamine.
Stearamidopropyl dimethylamine at 2% in hair conditioners was not a contact sensitiser when tested neat or diluted to 30%. However, irritation reactions
were observed.
A 10-year retrospective study found that out of 46 patients with confirmed allergic eyelid dermatitis, 10.9% had relevant reactions to oleamidopropyl
dimethylamine and 4.3% had relevant reactions to cocamidopropyl dimethylamine.
Most undiluted cationic surfactants satisfy the criteria for classification as Harmful (Xn) with R22 and as Irritant (Xi) for skin and eyes with R38 and R41.
The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles,
scaling and thickening of the skin.
Amphoteric surfactants are easily absorbed in the gut and partly excreted unchanged in the faeces. It has not been shown to accumulate in the body.
Concentrated betaines are expected to irritate the skin and eyes, but dilute solutions only irritate the eyes.
No evidence of delayed contact hypersensitivity was found in animal testing.
* [Van Waters and Rogers] ** [Canada Colors and Chemicals Ltd.] Toxicokinetics, metabolism and distribution. Absorption of the chemical across dermal
and gastrointestinal membranes is possible based on the relatively low molecular weight of the chemical (500 Da) and given that it is a surfactant (EC,
2003). Acute toxicity. Acute oral toxicity studies in rats and mice indicated that the LD50 values of the chemical (at 30-35.61% concentration) ranged from
1800 mg/kg bw (male rats) up to 5000 mg/kg bw, with mortalities noted in most studies (CIR, 2010). Of note is an acute oral toxicity study conducted in
Sprague-Dawley rats (5/sex) at a single dose of 1800 mg/kg bw (formulation containing 35.61% of the chemical), where no males but all five females died.
Overall, the data suggests that mortality occurs following oral administration of the chemical and that it may be an acute oral toxicant. Therefore, based on
these data the chemical may be harmful if swallowed. An acute dermal toxicity study in rats was conducted using 2000 mg/kg bw of a 31% formulation of the
chemical (CIR, 2010). Irritation was observed, but there were no clinical signs of systemic toxicity or mortalities. The lack of effects in this study suggests
that the chemical is likely to be of low acute dermal toxicity. Irritation. The chemical has a quaternary ammonium functional group, which is a structural alert
for corrosion Numerous skin irritation studies, conducted with formulations containing 7.5-30% of the chemical, indicated that the chemical has irritant
Chemwatch:
4789-88
Version No:
3.1.1.1
Page
5
of
8
NV Chemicals Sugar Soap Liquid
Issue Date:
26/01/2018
Print Date:
31/01/2018
Continued...